Mast cell activation syndrome and covid19 vaccine These cookies may also be used for advertising purposes by these third parties. Cutaneous findings following COVID-19 vaccination: review of world Bethesda, MD 20894, Web Policies COVID arm may feel mildly uncomfortable, but the reaction is not dangerous and will clear on its own. Administer vaccines that may be more likely to cause a local reaction (e.g., tetanus-toxoid-containing and PCV13) in different limbs, if possible. The majority of systemic reactions were mild or moderate in severity, after both doses. The majority of solicited systemic reactions occurred within the first 2 days after each, persisting for a median of 2 days. Fever, headache, abdominal pain, diarrhea, nausea, and vomiting can happen after live typhoid vaccine. of our COVID-19 coverage. You may want to consider talking with your doctor to learn more about the COVID-19 vaccines benefits and side effects. The unsolicited adverse event of COVID-19 within 28 days of any dose was more frequently reported in the placebo group (1.0%) than the vaccine group (0.2%). xhr.open('POST', 'https://www.google-analytics.com/collect', true); avatar 2 showtimes near touchstar cinemas spring hill 8 raspberry pi pico sleep mode micropython sims 4 toddler and child cc folder tforce ram sekkaku cheat wo . And for more vaccine news to know, find out why If You're Over 65, You Shouldn't Get This New Vaccine, Experts Warn. Such reactions can cause some pain and other symptoms around the. Let's discuss how this can affect different ages and how to, The most commonly reported side effect from the vaccine is injection site reaction. However, if you do experience a severe allergic reaction, it will usually happen immediately after receiving the injection. Axillary swelling or tenderness was reported more frequently post dose 1 (23.2%) than dose 2 (21.0%). Unable to load your collection due to an error, Unable to load your delegates due to an error, An old man had a history of intense itch and erythematous skin lesions after his first, Chilblainlike lesions (a) on the left big toe of a patient who had received his first shot, Widespread purpuric rash on the left thigh (a) of an elderly male which had developed a few days after his first, A young healthy female had a history of an asymptomatic petechial rash developing 1day after her first, Showing a female patient with a 2week history of widespread dry purpuric skin lesions on her extremities (a). Because pain can increase with each injection, the order in which vaccines are injected matters. Possible Side Effects After Getting a COVID-19 Vaccine | CDC During the study period, there were 322 patients referred for post-COVID-19 vaccine cutaneous reactions. First Detailed Look at COVID Vaccine Skin Reactions The connection between COVID-19 vaccines and lumps in women if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { Why Baby Has A Hard Lump On Leg After Vaccination - BabyGaga It resolves on its own within a few days. doi: 10.1111/jdv.18418. If you have questions about receiving a COVID-19 vaccination at a specific location, please contact that location. Thank you for taking the time to confirm your preferences. (b) In presence of secondary allergens, increased COVID19 vaccinemediated immune recruitment may manifest as delayed (type IV) allergic reactions, such as COVID arm, maculopapular rashes, erythema multiforme and dermal filler reactions. Epub 2023 Jan 2. Urticaria was . (2022). No grade 4 local reactions were reported. Clinical information and materials on COVID-19 vaccine products can be found here. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. In a CDC report on the Moderna vaccine, the agency said that the swelling of lymph nodes, also known as lymphadenopathy, can occur in either the arm or the neck. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. 2021 Jul;85(1):46-55. doi: 10.1016/j.jaad.2021.03.092. According to the CDC's report, these lumps typically appear two to four days after your vaccination, but only last about one to two days. the spike-protein sequences used to design the vaccines) and human components and may thus explain some COVID-19 pathologies as well as adverse skin reactions to COVID-19 vaccinations. c Fatigue, Myalgia, Arthralgia Grade 3: significant; prevented daily activity; Grade 4: required emergency room visit or hospitalization. The proportions of participants who reported at least one serious adverse event were 0.2% in the vaccine group and 0.2% in the placebo group. This potential side effect hasn't been as widely discussed as others. The frequency of local reactions was higher in the younger age group (aged 18 to 64 years) than the older age group (aged 65 years) (90.5% vs 83.9% after dose 2). The development of a nodule at the injection site is a known but rare adverse event following immunisation (AEFI). Stay up to date with COVID-19 vaccines including boosters. Before Lindgren AL, et al. Careers. This site needs JavaScript to work properly. Moving your arm and using a cool compress should help soothe the pain. For older children and adults, the deltoid muscle can be used for more than one intramuscular injection. A few days prior to presentation in our hospital, she had a history for spontaneous gastrointestinal, genital, nasal and oral bleedings (b). Vaccine Administration Route and Site | CDC Trial data has shown that the Pfizer-BioNTech and Moderna vaccines are safe and generally well tolerated. In Victoria reports can be made to SAEFVIC. Often, more than one vaccine is needed during the same doctors visit, requiring more than one shot. A recent study by the National Institute of Health (NIH) also found that these vaccines are effective, leading to a low hospitalization rate with severe symptoms or death from COVID-19. Autoimmune-mediated skin findings after COVID-19 vaccination include leucocytoclastic vasculitis, lupus erythematosus and immune thrombocytopenia. 2022 Dec;36(12):e979-e981. (a) Immediate (type I), MeSH In the older age group, the most common serious adverse event occurring at higher rates in the vaccine group than the placebo group was pneumonias (2 cases in vaccine group vs. 0 cases in placebo group). A higher frequency of unsolicited adverse events was reported in the vaccine group compared to the placebo group and was primarily attributed to local and systemic reactogenicity following vaccination. If you experience soreness, redness, swelling, or an itchy rash at the injection site about a week after getting the booster, you likely have COVID arm. In this review article, we provide a brief overview on cutaneous findings that have been observed since the emerging mass COVID-19 vaccination campaigns all over the world. xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); We take your privacy seriously. While less rare than anaphylaxis, this is still pretty uncommon. Ensure correct vaccine administration for both intramuscular and subcutaneous vaccines. A higher frequency of unsolicited adverse events was reported in the vaccine group compared to the placebo group (29.6% vs 25.1%). The COVID-19 vaccine can cause some commonly known side effects. Vaccine recipients reported similar rates of local reactions after dose 1 and dose 2, but slightly lower after dose 3. Its symptoms appear several days to a week after the first or second vaccination. The .gov means its official. (2022). Injection site reactions. 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. Materials in this section are updated as new information and vaccines become available. (2021). . c Axillary swelling or tenderness was collected as a solicited local adverse reaction (i.e., lymphadenopathy: localized axillary swelling or tenderness ipsilateral to the vaccination arm); grade 3: any use of prescription pain reliever or prevented daily activity; grade 4: required emergency room visit or hospitalization. Occupational Safety and Health Administration (OSHA) regulations typically do not required gloves to be worn when administering vaccines unless the person administering the vaccine is likely to come in contact with potentially infectious body fluids or has open lesions on the hands. Usually, this lump or swelling will appear within 24 hours of the vaccination and lasts for anywhere from three to seven days afterward. Axillary (or groin) swelling or tenderness was reported slightly more frequently in the younger age group than the older age group (9.3% vs 9.1% after dose 2). The AstraZeneca vaccine Vaxzevria is a vaccine against COVID-19. Itching, pain, and swelling are the main symptoms. *Based on age. Axillary swelling or tenderness was the second most frequently reported local reaction. 2021 The Authors. If 1 of These 3 Body Parts Starts Swelling Up After Your Vaccine, Call A higher frequency of unsolicited adverse events after any dose was reported in the vaccine group (20.5%) compared to the placebo group (15.9%). Vaccine recipients reported higher rates of local reactions after dose 2 than dose 1. This article reviews all you need to, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. All information these cookies collect is aggregated and therefore anonymous. Disclaimer. Doctors and the CDC say this coronavirus. 2023 Feb 20:1-4. doi: 10.1007/s13691-023-00598-7. scientific studies and medical journals. Frequently Asked Questions about COVID-19 Vaccination | CDC Catal A, Muoz-Santos C, Galvn-Casas C, Roncero Riesco M, Revilla Nebreda D, Sol-Truyols A, Giavedoni P, Llamas-Velasco M, Gonzlez-Cruz C, Cubir X, Ruz-Villaverde R, Gmez-Armayones S, Gil Mateo MP, Pesqu D, Marcantonio O, Fernndez-Nieto D, Roman J, Iglesias Pena N, Carnero Gonzalez L, Tercedor-Sanchez J, Carretero G, Masat-Tic T, Rodrguez-Jimnez P, Gimenez-Arnau AM, Utrera-Busquets M, Vargas Laguna E, Angulo Menndez AG, San Juan Lasser E, Iglesias-Sancho M, Alonso Naranjo L, Hiltun I, Cutillas Marco E, Polimon Olabarrieta I, Marinero Escobedo S, Garca-Navarro X, Caldern Gutirrez MJ, Baeza-Hernndez G, Bou Camps L, Toledo-Pastrana T, Guilabert A. Br J Dermatol. A safety recall issued by the manufacturer affects 460,769 cars around the world. Other serious adverse events in the vaccine group included dehydration, metapneumovirus, foreign body respiratory tract infection, mastoiditis, bronchiolitis, pyrexia, rhinovirus, asthma, adenovirus infection, erythema multiforme, croup infectious, viral gastroenteritis, and 1 participant with Type 1 diabetes and diabetic ketoacidosis. Injection site reactions are areas of skin redness, swelling, and warmth. Less than 50% of people who got COVID arm after their first dose will get it after their second. The Melbourne Vaccine Education Centre (MVEC) staff regularly reviews materials for accuracy. If possible, administer COVID-19 vaccine and other reactogenic vaccines (e.g., MenB, Tdap) in different limbs. We avoid using tertiary references. There were no other systemic grade 4 reactions reported. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Local reactions in both groups were mostly grade mild or moderate; however, severe reactions were more frequent in the vaccine group than in the placebo group. Purvi Parikh, MD, an immunologist with Allergy & Asthma Network and a co-investigator on COVID-19 vaccine trials at NYU, told Popsugar that swollen lymph nodes are just one way in which your body may show that it is building an immune response. While not impossible, it is less likely to occur with a booster shot if you havent experienced it before. They usually present in the days or weeks following immunisation and are most often reported following vaccines given in infancy or childhood. The reactogenicity profile of the vaccines (It is unknown whether reactogenicity of COVID-19 vaccine is increased with coadministration, including with other vaccines known to be more reactogenic, such as adjuvanted vaccines or live vaccines). If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. They usually resolve spontaneously without treatment or investigation. Cookies used to make website functionality more relevant to you. **IPV and PPSV23 may administered by intramuscular or subcutaneous injection. Skin reactions to COVID-19 vaccines. Elyoussfi DS, et al. COVID-19 is a life threatening condition, and the vaccine is highly protective against the virus SARS-CoV-2, which causes COVID-19. Vaccines available in the United States are administered by 4 routes: When administering a vaccine by injection, choose the correct needle size based on the route, age, patient size, and injection technique. Very rarely, a nodule may persist and become symptomatic for the vaccinee (see rare or persisting subcutaneous nodules below). Use combination vaccines (e.g., DTaP-IPV-HepB or DTaP-IPV/Hib) to reduce the number of injections, when appropriate. Unsolicited AEs were collected during the 28 days after each dose. People sometimes faint after medical procedures, including vaccination. All health care professionals who administer vaccines to older children, adolescents, and adults should be aware of the potential for syncope after vaccination and the related risk of injury caused by falls. Recently, people who have been vaccinated are sharing stories online about feeling lumps in their armpits, which might seem like cause for concern, but is in fact, to be expected. An official website of the United States government. CDC twenty four seven. urticaria, angio-oedema and anaphylaxis) likely due to allergy to ingredients may rarely occur but can be severe. The vaccines often cause swelling in the armpit or underarm that can mimic the lumps associated with breast cancer, causing some women undue concern. A 2021 case report showed that the Pfizer-BioNTech vaccine might also cause COVID arm but appears less likely to do so. a mild: 25-50 mm; moderate: 51-100 mm; severe: >100 mm; Grade 4=necrosis or exfoliative dermatitis. Adverse events in the vaccine group were similar in nature and incidence to those in the placebo group, with the exception of higher incidence of injection site erythema in the vaccine group compared to the placebo group (1.3% vs 0.2%) and COVID-19 in the placebo group compared to the vaccine group (5.5% vs 3.1%). Pain from the shot, redness, or swelling at the site of the injection, fever, and headache, and general discomfort can happen after inactivated typhoid vaccine. 2023 Feb 6:S0365-0596(23)00008-9. doi: 10.1016/j.abd.2022.04.010. (2021). However, all vaccination providers should be familiar with the office emergency plan and currently certified in cardiopulmonary resuscitation. Paolino G, Di Nicola MR, Rizzo N, Mercuri SR. An Bras Dermatol. Clipboard, Search History, and several other advanced features are temporarily unavailable. Label each syringe with the name and the dosage (amount) of the vaccine, lot number, the initials of the preparer, and the exact beyond-use time, if applicable. Fever was more common after the second dose and in the younger group (17.6%) compared to the older group (10.2%). ACS Central Sci 2021; 7: 512533. Administer vaccines that are known to be painful when injected (e.g., MMR, HPV) last. "Reports of lymphadenopathy were imbalanced with 1.1 percent of persons in the vaccine group and 0.6 percent in the placebo group reporting such events," the CDC notes. It is unclear what causes a nodule however, vaccine components (e.g. There was one report of grade 4 fatigue and one report of grade 4 arthralgia, both in the younger age group after dose 1. e Chills Grade 3: prevented daily activity and required medical intervention; Grade 4: required emergency room visit or hospitalization. If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing Why Monkeypox Messaging Matters To Reduce LGBTQ Stigma, Everything You Ever Wanted to Know About the Rabies Vaccine, Glycemic Index: What It Is and How to Use It, a red or discolored rash that varies in size from quarter-sized to very large, in some instances, the rash may spread to your hands or fingers, hard lump under your skin where the injection took place. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your familys personal health. The frequency and severity of systemic reactions was higher after dose 2 than dose 1 (78.1% vs 57.9%). and transmitted securely. Pain at the injection site was more common post Dose 2 (94.8%) than Dose 1 (93.1%). If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Selected adverse events reported after COVID-19 vaccination. This reaction and others are continuing to be studied worldwide. (2021). Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. Headache and fatigue were the most common reactions. if( navigator.sendBeacon ) { The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The history of, or presence of, a nodule is not a contraindication to future vaccines. These cookies may also be used for advertising purposes by these third parties. While this might seem strange or alarming, doctors want to assure patients that it's actually totally normal, even though it's on the rare side as far as side effects go. Your immune cells respond to the muscle cells that have absorbed the mRNA vaccine. . E, et al Nodule at injection site as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation, Vaccine 2004 (22): 575-585, Silcock, R. et al Subcutaneous nodules following immunization in children; in Victoria, Australia from 2007 to 2016, Vaccine 2020 (38): 3169-3177, Silcock, R. et al Subcutaneous nodules: an important adverse event following immunization, Expert Review of Vaccines 2019 (18): 405-410, Bergfors, E. Lundmark, K. Kronander, U. Redness and swelling were slightly more common after dose 2. Healthline Media does not provide medical advice, diagnosis, or treatment. Get the details on dosage, side effects, cost, and more. Ann Dermatol. We are committed to honouring Australian Aboriginal and Torres Strait Islander peoples unique cultural and spiritual relationships to the land, waters and seas. Sanomachi T, Sumiyoshi Okuma H, Yonemori K. Int Cancer Conf J. Pfizer-BioNTech COVID-19 Vaccine Reactions & Adverse Events Procedural Pain Management Some nodules can become symptomatic and last for months or even years and are referred to as persisting subcutaneous nodules. Although pain from injections is, to some extent, unavoidable, there are some things that parents and health care providers can do to help prevent distress and decrease fear. The most common serious adverse events occurring at higher rates in the vaccine group than the placebo group were myocardial infarction (5 cases in vaccine group vs. 3 cases in placebo group), cholecystitis (3 vs. 0), and nephrolithiasis (3 vs. 0). xhr.send(payload); Detailed discussion can be found here: Pinkbook: Vaccine Administration | CDC Grade 4 fever (>40.0C) was reported by four vaccine recipients after dose 1 and 11 vaccine recipients after dose 2. But in rare. The rabies vaccine can save your life after a bite or scratch from an unvaccinated animal. COVID-19 Vaccination Locations on VaccineFinder | CDC Our website services, content, and products are for informational purposes only. The lymphatic system is home to your immune system; so when you get checked out for a cold or strep throat or flu, your doctor will feel your neck area. At-home treatments that reduce pain, swelling, and itching include: COVID arm is a minor annoyance that will disappear within a few days. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy. No grade 4 local reactions were reported. The COVID-19 vaccines are beginning to significantly slow the spread of the virus, but the Pfizer and Moderna and vaccines are having an unforeseen consequence for breast cancer doctors. 2022 Jan;186(1):142-152. doi: 10.1111/bjd.20639. A rare coronavirus vaccine side effect that some people have experienced, however, is a lump in the armpit of the arm in which they've been vaccinated. Curr Opin Virol 2021; 49: 5257. Read on to find out more about this reaction and for another heads-up about vaccinations, know that This COVID Vaccine Side Effect Could Show Up a Week After Your Shot. Note: No grade 4 local reactions were reported. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. From Immunogen to COVID-19 vaccines: Prospects for the post-pandemic era. Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. Lymphadenopathy occurred in the arm and neck region and was reported within 2 to 4 days after vaccination. For infants and younger children receiving more than two injections in a single limb, the thigh is the preferred site because of the greater muscle mass. It typically occurs around one week after the first or second shot vaccination. One grade 4 fever was erroneously reported in the placebo group after dose 1. The overall incidence of unsolicited adverse events up to 28 days after any dose were similar in the vaccine group (49.3%) and the placebo group (48.2%) for participants ages 523 months. Lump Behind the Ear: Possible Causes Explained - Verywell Health Bojan Story/Getty Images. If You Have a Skin Reaction to the Moderna COVID-19 Vaccine, Don't Panic -, Vasireddy D, Atluri P, Malayala SV, Vanaparthy R, Mohan G. Review of COVID19 Vaccines Approved in the United States of America for Emergency Use. Currently available information is insufficient to determine a causal relationship with the vaccine. The proportions of participants who reported at least one serious adverse event were 0.5% in the vaccine group and 0.2% in the placebo group. If multiple vaccines are administered at a single visit, administer each injection in a different injection site. It wont escalate to a life threatening condition or serious allergic reaction and is not associated with anaphylaxis. Ramos CL, et al. Detailed discussion can be found here: Multiple Injections/Coadministration of Vaccines, COVID-19 vaccine and coadministration with other vaccines, Routine and Influenza Immunization Services During the COVID-19 Pandemic: Interim Guidance | CDC, Vaccine Administration: Intramuscular (IM) Injection Children 7 through 18 years of age, Vaccine Administration: Intramuscular (IM) Injection Adults 19 years of age and older], Vaccine Administration: Needle Gauge and Length, Giving all the Doses Under 12 Months of Age, COVID-19 vaccines can be given during the same visit, How to Hold Your Child During Vaccinations, General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP), Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline, Subcutaneous (SC or Subcut) Injection: Sites [3:26 minutes], Subcutaneous (SC or Subcut) Injection: Administration [6:27 minutes], Intramuscular Injection: Sites [5:07 minutes], Live, Attenuated Influenza Vaccine (LAIV) [4:09 minutes], Comfort and Restraint Techniques for Children [4:46 minutes], You Call the Shots: Vaccine administration training for healthcare professionals, National Center for Immunization and Respiratory Diseases, Healthcare Professionals / Providers Home, Vaccine Adverse Event Reporting System (VAERS), Pediatric Vaccination Practices During COVID-19, Childhood Vaccination Toolkit for Clinicians, You Call The Shots: Vaccine Storage and Handling, Screen for Contraindications and Precautions, Temporary, Satellite, or Off-Site Vaccination Clinics, Easy-to-Read Recommended Immunization Schedules, Resources for Parents of Infants and Toddlers, Resources for Parents of Preteens and Teens, Resources for College Students, Young Adults, and Adults, Understanding Risks & Responsibilities, If You Choose Not to Vaccinate, Talking with Parents about Vaccines for Infants, Understanding Vaccines and Vaccine Safety, U.S. Department of Health & Human Services, DTaP, DT, HepA, HepB, Hib, HPV, , IIV4, RIV4, ccIIV4, IPV*, MenACWY, MenB, PCV13, PPSV23*, RZV, Td, Tdap, TT, Fatty tissue of thigh for infants younger or upper outer triceps area, DTaP-IPV, DTaP-IPV-HepB, DTaP-IPV/Hib, DTaP-IPV-HepB/Hib, HepA-HepB. No specific safety concerns were identified among vaccine recipients aged 6 months5 years. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. J Am Acad Dermatol. Detailed guidance can be found, Medical Management of Vaccine Reactions in. Symptoms are usually mild and localised to the site of vaccination, with onset commonly occurring within the first 48 hours of vaccination and symptoms lasting 1-2 days. Any treatments would need to be provided following medical review and can include topical corticosteroids or dressings to protect the area from rigorous scratching. Enlarged lymph nodes are common after the Covid-19 vaccine and are your body's normal reaction to the vaccine. The majority of these events of lymphadenopathy occurred in the arm and neck region. The CDC recommends an mRNA vaccine over the J&J vaccine. Type IV hypersensitivity reactions may be observed, including delayed large local skin lesions ("COVID arm"), inflammatory reactions in dermal filler or previous radiation sites or even old BCG scars, and more commonly morbilliform and erythema multiforme-like rashes. Drago F, Ciccarese G, Guadagno A, Parodi A. J Eur Acad Dermatol Venereol. During the COVID-19 pandemic, gloves should be worn when administering intranasal or oral vaccines. Fever was more common after the second dose (12.1%) compared to the first dose (2.5%). Axillary (or groin) swelling or tenderness and injection site swelling following either dose were reported less frequently and were more common after dose 2. Pain/tenderness at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. If youre worried about COVID arm, keep in mind that the protective benefits of the COVID-19 vaccine far outweigh the risks associated with COVID arm or developing COVID-19 itself. Considerations for Coadministration of COVID-19 Vaccines and Other Vaccines. asevere: >10 cm; Grade 4: necrosis (redness and swelling categories) or exfoliative dermatitis (redness category only). (Table 10, Table 11). COVID arm is a rare reaction. COVID-19 Vaccine Side Effects: What to Know Now - Healthline They tend to appear a few days post-vaccination. (d) Generation of autoreactive lymphocytes and crossreactive antibodies due to molecular mimicry leading to autoimmune reactions, such as vaccineinduced immune thrombocytopenia (VIIT) lupus erythematosus, vasculitis and bullous pemphigoid. COVID arm is a harmless immune system reaction that some people have after getting the Moderna vaccine. Accessibility New Vaccine Side Effect "COVID Arm" Striking Patients, Say Doctors And for more up-to-date COVID news delivered right to your inbox, sign up for our daily newsletter. -, Li Y, Tenchov R, Smoot J, Liu C, Watkins S, Zhou Q.